The Center for Ultrasound Molecular Imaging and Therapeutics is a multidisciplinary translational research facility designed to develop the science and technology of ultrasound contrast agents and ultrasound imaging systems, including microbubble technology, with the goal of moving basic discoveries in ultrasound-based molecular imaging and treatments into clinical practice. The Center facilities include two acoustic laboratories with all necessary equipment to drive and receive custom ultrasound signals; chemistry and molecular biology laboratories; facilities for tissue culture and tissue processing for histology; three laboratories for intravital microscopy; a cardiac catheterization laboratory; and four laboratories for acute and survival animal surgery.
The Center’s research imaging capabilities include, but are not limited to:
- small animal (rodent) 2D ultrasound imaging with 3D reconstruction capabilities;
- large animal 2D ultrasound imaging; precise cross sectional imaging and 3D reconstruction for tumor volume measurements;
- tissue perfusion imaging using contrast agents in combination with ultrasound systems with non-linear (contrast-specific) imaging capabilities;
- molecular imaging using targeted ultrasound contrast agents and facilities for synthesis and characterization of ultrasound contrast agents (including microbubbles and liposomes), and imaging systems for their detection;
- ultrahigh speed microscopic imaging (e.g., of microbubbles in an acoustic field), including high speed fluorescence imaging; and
- acoustic tank set-ups for in vitro ultrasound imaging.